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What Is The Role Of A Herg Assay?

The human ether-a-go-go related gene (hERG) channels control the inward voltage-gated potassium current IKr that defines ventricular repolarization. Drug-induced inhibition of hERG leads to QT interval prolongation and proarrhythmic events such as Torsade de Pointes. Non-GLP hERG assay screening is recommended by health authorities and regulatory agencies as an early test in drug discovery to […]

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